Overexpression of the Response Regulator evgA of the Two-Component Signal Transduction System Modulates Multidrug Resistance Conferred by Multidrug Resistance Transporters

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Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters.

Overexpression of evgA, a response regulator of a two-component system, increased multidrug efflux in Escherichia coli. Since overexpression of the emrKY operon, which is controlled by evgAS, could account only for deoxycholate resistance, the evgAS locus apparently controls expression of at least one other multidrug efflux operon.

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Multidrug resistance associated proteins in multidrug resistance

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 2001

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.183.4.1455-1458.2001